Effect of aceclofenac on pharmacokinetics of phenytoin sodium in epileptic patients
نویسندگان
چکیده
منابع مشابه
Effect of aceclofenac on pharmacokinetic of phenytoin.
Aceclofenac is presently most commonly prescribed analgesic for chronic pain and inflammatory conditions. In clinical practice, phenytoin and aceclofenac are used in a chronic condition of generalized seizure with concomitant chronic pain. Hence there are chances of drug-drug interaction because modulations of isoenzymes involved in metabolism of phenytoin and aceclofenac are CYP2C9/10 and CYP2...
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The study determined the population estimates for Km and Vmax of phenytoin in Thai patients. The serum phenytoin concentrations collected prospectively from outpatients who received phenytoin were analyzed to estimate population pharmacokinetic parameters. There were 197 steady-state concentrations and associated dosage rates (mg/day) from 167 outpatients. The data were analyzed using NONMEM, a...
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ژورنال
عنوان ژورنال: International Journal of Basic & Clinical Pharmacology
سال: 2018
ISSN: 2279-0780,2319-2003
DOI: 10.18203/2319-2003.ijbcp20183922